A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer

Frontiers in Oncology

Soudeh Ghafouri-Fard¹  Bashdar Mahmud Hussen²  Mohammad Taheri³  Tayybeh Khoshbakht⁴  Majid Mokhtari⁵ 

[1] Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq;Institute of Human Genetics, Jena University Hospital, Jena, Germany;Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: AFAP1-AS1;    cancer;    biomarker;    expression;    ncRNA;   

DOI  :  10.3389/fonc.2021.777849

来源: DOAJ

【 摘 要 】

AFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP1-AS1 can sequester a number of cancer-related miRNAs, thus affecting activity of signaling pathways involved in cancer progression. Most of animal studies have confirmed that AFAP1-AS1 silencing can reduce tumor volume and invasive behavior of tumor cells in the xenograft models. Moreover, statistical analyses in the human subjects have shown strong correlation between expression levels of this lncRNA and clinical outcomes. In the present work, we review the impact of AFAP1-AS1 in the carcinogenesis.

【 授权许可】

Unknown