A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion

Frontiers in Molecular Biosciences

Soudeh Ghafouri-Fard¹  Bashdar Mahmud Hussen²  Mohammad Taheri³  Tayyebeh Khoshbakht⁴  Mohammad Samadian⁵ 

[1] Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq;Institute of Human Genetics, Jena University Hospital, Jena, Germany;Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: miR-1290;    cancer;    biomarker;    miRNA;    expression;   

DOI  :  10.3389/fmolb.2021.763338

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) have been shown to affect expression of several genes contributing in important biological processes. miR-1290 a member of this family with crucial roles in the carcinogenesis. This miRNA is transcribed from MIR1290 gene on chromosome 1p36.13. This miRNA has interactions with a number of mRNA coding genes as well as non-coding RNAs SOCS4, GSK3, BCL2, CCNG2, KIF13B, INPP4B, hMSH2, KIF13B, NKD1, FOXA1, IGFBP3, CCAT1, FOXA1, NAT1, SMEK1, SCAI, ZNF667-AS1, ABLIM1, Circ_0000629 and CDC73. miR-1290 can also regulate activity of JAK/STAT3, PI3K/AKT, Wnt/β-catenin and NF-κB molecular pathways. Most evidence indicates the oncogenic roles of miR-1290, yet controversial evidence also exists. In the present review, we describe the results of in vitro, animal and human investigations about the impact of miR-1290 in the development of malignancies.

【 授权许可】

Unknown