De novo peroxisome biogenesis revisited

Microbial Cell

Ida J. van der Klei¹  Marten Veenhuis¹ 

[1] Molecular Cell Biology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.;

关键词: yeast;    peroxisomes;    de novo peroxisome formation;    peroxisome deficient mutant;    endoplasmic reticulum;   

DOI  :  10.15698/mic2014.04.138

来源: DOAJ

【 摘 要 】

We describe an alternative peroxisome formation pathway in yeast pex3 and pex19 cells, which relies on the existence of small peroxisomal remnants that are present in these cells. This groundbreaking result challenges current models prescribing that peroxisomes derive de novo from the ER. Our data also has major implications for the sorting pathway of specific peroxisomal membrane proteins (PMPs). We propose a novel sorting pathway for the PMPs Pex13 and Pex14 that is independent of the known Pex3/Pex19 machinery.

【 授权许可】

Unknown