From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization

Antibodies

Léna Absi¹  Sandrine Laradi²  Nicolas Maillard²  Christophe Mariat²  Chaker Aloui²  Olivier Garraud²  Fabrice Cognasse²  Antoine Prigent² 

[1] EFS Auvergne-Loire, 42023 Saint-Etienne, France;GIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, France;

关键词: transfusion;    transplantation;    alloimmunization;    tolerance;    HLA;   

DOI  :  10.3390/antib3010130

来源: DOAJ

【 摘 要 】

Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses.

【 授权许可】

Unknown