From Donor to Recipient: Current Questions Relating to Humoral Alloimmunization

Antibodies

Antoine Prigent¹  Nicolas Maillard¹  Léna Absi²  Chaker Aloui¹  Fabrice Cognasse¹  Sandrine Laradi¹  Christophe Mariat¹ 

[1] GIMAP-EA3064, Université de Lyon, 42023 Saint-Etienne, France;EFS Auvergne-Loire, 42023 Saint-Etienne, France

关键词: transfusion;    transplantation;    alloimmunization;    tolerance;    HLA;   

DOI  :  10.3390/antib3010130

来源: mdpi

【 摘 要 】

Alloimmunization is an undesirable iatrogenic effect of transfusion and transplantation. In fact, recipients can be considered as responders or not responders, in a continuum from tolerance, including organ transplantation and transfusion, to polyimmunized and refractory patients. New models and large studies have enabled a better understanding of the mechanisms that induce specific alloantibody (alloAb) generation. Here, we focus on risk factors of alloimmunization. We review the alloantibody characteristics, summarize the different leukocytes involved in their induction, and suggest some hypotheses.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.