New approaches to radiation protection

Frontiers in Oncology

Eliot Michael Rosen¹ 

[1] Georgetown University School of Medicine;

关键词: Radiation Protection;    irradiation;    cancer treatment;    Radioprotectors;    Mitigators;   

DOI  :  10.3389/fonc.2014.00381

来源: DOAJ

【 摘 要 】

Radioprotectors are compounds that protect against radiation injury when given prior to radiation exposure. Mitigators can protect against radiation injury when given after exposure but before symptoms appear. Radioprotectors and mitigators can potentially improve the outcomes of radiotherapy for cancer treatment by allowing higher doses of radiation and/or reduced damage to normal tissues. Such compounds can also potentially counteract the effects of accidental exposure to radiation or deliberate exposure (eg., nuclear reactor meltdown, dirty bomb, or nuclear bomb explosion); hence the are called radiation countermeasures. Here we will review the general principles of radiation injury and protection and describe selected examples of radioprotectors/mitigators ranging from small molecules to proteins to cell-based treatments. We will emphasize agents that are in more advanced stages of development.

【 授权许可】

Unknown