Oleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction

Frontiers in Cell and Developmental Biology

关键词: Caenorhabditis elegans;    longevity;    reproduction;    oleic acid;    mating-induced death;    metabolism;   

DOI  :  10.3389/fcell.2021.690373

来源: DOAJ

【 摘 要 】

Reproduction comes at a cost, including accelerated death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed in low-reproduction conditions. To understand how increased reproduction affects lifespan and fat metabolism, we examined mated worms; we find that a Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation of oleic acid (OA), the immediate downstream product of FAT-7 activity, restores fat storage and completely rescues mating-induced death, while other fatty acids cannot. OA-mediated lifespan restoration is also observed in C. elegans mutants suffering increased death from short-term mating, and in mated C. remanei females, indicating a conserved role of oleic acid in post-mating lifespan regulation. Our results suggest that increased reproduction can be uncoupled from the costs of reproduction from somatic longevity regulation if provided with the limiting lipid, oleic acid.

【 授权许可】

Unknown