Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF‐1 signaling pathways in C. elegans

Aging Cell

Keunhee Seo¹  Eunseok Choi¹  Dongyeop Lee¹  Dae-Eun Jeong¹  Sung Key Jang¹ 

[1] Department of Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, Korea

关键词: aging;    Caenorhabditis elegans;    HSF‐1;    insulin/IGF‐1 signaling;    longevity;    mRNA translation;    S6 kinase;    target of rapamycin;   

DOI  :  10.1111/acel.12140

来源: Wiley

【 摘 要 】

Summary

Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose inhibition extends the lifespan of yeast, Caenorhabditis elegans, Drosophila, and mice. Here, we demonstrate that the activation of heat shock factor 1 (HSF-1), a crucial longevity transcription factor known to act downstream of the insulin/IGF-1 signaling (IIS) pathway, mediates the prolonged lifespan conferred by mutations in C. elegans S6K (rsks-1). We found that hsf-1 is required for the longevity caused by down-regulation of components in TOR signaling pathways, including TOR and S6K. The induction of a small heat-shock protein hsp-16, a transcriptional target of HSF-1, mediates the long lifespan of rsks-1 mutants. Moreover, we show that synergistic activation of HSF-1 is required for the further enhanced longevity caused by simultaneous down-regulation of TOR and IIS pathways. Our findings suggest that HSF-1 acts as an essential longevity factor that intersects both IIS and TOR signaling pathways.

【 授权许可】

Unknown   
© 2013 the Anatomical Society and John Wiley & Sons Ltd