Chemical composition, antioxidant and antitumor activities of sub-fractions of wild and cultivated Pleurotus ferulae ethanol extracts

PeerJ

Xiaoqin Li¹  Xiaoyu Luo²  Jinyao Li²  Fangfang Zhou²  Changshuang Fu²  Yi Yang²  Jinyu Li³  Jiang He⁴  Jun Zhao⁴ 

[1] Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China;College of Life Science and Technology, Xinjiang University, Urumqi, China;College of Life Science, Xinjiang Normal University, Urumqi, China;Key Laboratory for Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, China;

关键词: Ethanol extract;    Pleurotus ferulae;    Antioxidation;    Apoptosis;    Antitumor;   

DOI  :  10.7717/peerj.6097

来源: DOAJ

【 摘 要 】

Pleurotus ferulae is an edible and medicinal mushroom with various bioactivities. Here, the ethanol extracts of wild and cultivated P. ferulae (PFEE-W and PFEE-C) and their subfractions including petroleum ether (Pe-W/Pe-C), ethyl acetate (Ea-W/Ea-C) and n-butanol (Ba-W/Ba-C) were prepared to evaluate their antioxidant and antitumor activities. Both PFEE-W and PFEE-C show the antioxidant activity and PFEE-W is stronger than PFEE-C. The antioxidant activities of their subfractions are in the following order: Ea > Ba > Pe. Moreover, PFEE-W and PFEE-C significantly inhibit the proliferation of murine melanoma B16 cells, human esophageal cancer Eca-109 cells, human gastric cancer BGC823 cells and human cervical cancer HeLa cells through induction of apoptosis, which partially mediated by reactive oxygen species. The antitumor activities of their subfractions are in the following order: Ea ≥ Pe > Ba. Pe-W shows higher antitumor activity compared with Pe-C, which might be correlated with the difference of their components identified by gas chromatography-mass spectrometry. These results suggest that both wild and cultivated P. ferulae have antioxidant and antitumor activities, and cultivated P. ferulae could be used to replace wild one in some functions.

【 授权许可】

Unknown