Thermal and spectroscopic studies of some metal complexes with a new enaminone ligand 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one and their investigation as anti-urease and cytotoxic potential drugs

Arabian Journal of Chemistry

Tariq Mahmud¹  Syeda Marium Hasany²  Shafi Ullah Khan³  Rahila Huma⁴  Amna Yousaf⁴  Muhammad Ashraf⁴  Sana Javaid Awan⁵  Humaira Rasheed⁶ 

[1] Corresponding author.;Department of Pharmacy, Abasyn University, Peshawar, Pakistan;Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan;Kinnaird College for Women, 93-Jail Road, Lahore 54000, Pakistan;School of Chemistry, University of the Punjab, Lahore 54590, Pakistan;School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor, Malaysia;

关键词: Anti-urease activity;    Cytotoxicity;    Enaminone;    Metal complexes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Complexes of transition metals [Co(II), Cd(II) and Mo(0)] with a new enaminone (PA) 3-chloro-4-((4-methoxyphenyl)amino)pent-3-en-2-one were synthesized and afterwards characterized by 1H NMR, 13C NMR, FAB-MS, UV–Vis, ICP-OES, TGA and FTIR. The spectroscopic and conductance data suggested that the ligand (PA) is attached to the metal ions in bidentate, neutral form through the nitrogen atom of amino group and the oxygen of carbonyl group. Metal complexes displayed octahedral geometries. In vitro urease inhibition and cytotoxic activities of all the compounds were evaluated. Results revealed that Co(II) complex (PA-Co) was even more significant than the reference drug thiourea. Analysis of the cytotoxicity indicated that, the Co(II) complex has more cytotoxic effect than enaminone ligand and other complexes when assessed on the human cancer cell lines MCF-7.Molecular docking simulation was also performed to find out the putative binding mode within the target protein.

【 授权许可】

Unknown