One pot four component sequential synthesis of hexahydroquinoline derivatives in aqueous media via enaminone intermediates: A green protocol

Journal of Saudi Chemical Society

P. Patil¹  D. Chandam²  M. Deshmukh²  D. Patil²  A. Mulik²  S. Jagdale² 

[1] Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur 416 004 (MS), India;Heterocyclic Research Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416 004 (MS), India;

关键词: Enaminone;    Sequential reaction;    Hantzsch reaction;    Crystal structure;    Michael reaction;   

DOI  :  10.1016/j.jscs.2014.04.001

来源: DOAJ

【 摘 要 】

A convenient green chemistry method through one pot four component tandem synthesis of hexahydroquinoline via enaminone intermediate using dimedone, ammonium acetate, aryl aldehydes and malononitrile has been described in aqueous media without the use of any external catalyst. The excess of ammonium acetate used acts as a reagent as well as catalyst. The incorporation of water as solvent along with eradication of external catalyst renders the protocol to comply with the green chemistry aspects. Shorter reaction time, high atom economy, easy work up and purification of products by non-chromatographic method are the crucial features of this methodology. The crystal structure of hexahydroquinoline basically shaped by chromatographic free selective reaction was determined by single crystal X-ray diffraction analysis.

【 授权许可】

Unknown