Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

Haliclona sp.;Bis-1;3-dialkylpyridiniums;Cyclostellettamines;Cytotoxicity;Antibacterial activity;615

약학대학 약학과 ;

University:서울대학교 대학원

关键词: Haliclona sp.;    Bis-1;    3-dialkylpyridiniums;    Cyclostellettamines;    Cytotoxicity;    Antibacterial activity;    615;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/133431/1/000000002850.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class were isolated from the sponge Haliclona sp. collected from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 and Gram-positive strains. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.