Cyclic Bis-1,3-dialkylpyridiniums from the Sponge Haliclona sp.

Marine Drugs

Yoonyeong Lee¹  Kyung Hwa Jang¹  Ju-eun Jeon¹  Woo-Young Yang²  Chung J. Sim³  Ki-Bong Oh² 

[1] Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea;Department of Agricultural Biotechnology, College of Agriculture & Life Science, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-921, Korea;Department of Biological Science, College of Life Science and Nano Technology, Hannam University, 461-6 Jeonmin, Yuseong, Daejeon 305-811, Korea;

关键词: Haliclona sp.;    bis-1;    3-dialkylpyridiniums;    cyclostellettamines;    cytotoxicity;    antimicrobial activity;   

DOI  :  10.3390/md10092126

来源: mdpi

【 摘 要 】

Eight novel cyclic bis-1,3-dialkylpyridiniums, as well as two known compounds from the cyclostellettamine class, were isolated from the sponge Haliclona sp. from Korea. Structures of these novel compounds were determined using combined NMR and FAB-MS/MS analyses. Several of these compounds exhibited moderate cytotoxic and antibacterial activities against A549 cell-line and Gram-positive strains, respectively. The structure-activity relationships of cyclostellettamines are discussed based on their bioactivities.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.