Steroidal Constituents from Roots and Rhizomes of Smilacina japonica

Molecules

Yuwen Cui¹  Haifeng Tang¹  Xinjie Yang²  Zhenggang Yue²  Xiaomei Song²  Li Zhang²  Yuze Li³  Bei Song³  Dongdong Zhang⁴ 

[1] Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, China;Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China;The College of Life Sciences, Northwest University, Xi’an 710069, China;The College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 200001, China;

关键词: Smilacina japonica;    steroidal constituents;    structure identification;    cytotoxicity;   

DOI  :  10.3390/molecules23040798

来源: DOAJ

【 摘 要 】

Four new steroidal constituents (1–4) along with two known steroidal glycosides (5 and 6) were isolated from the roots and rhizomes of Smilacina japonica. Analysis of their physicochemical properties and spectroscopic profiles identified the compounds as (25S)-5α-spirostan-9(11)-en-3β, 17α-diol (1); (25S)-5α-spirostan-9(11)-en-3β, 12β-diol (2); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranoside (3); (25S)-5α-spirostan-9(11)-en-3β, 17α-diol-3-O-β-d-glucopyranosyl-(1→2)-[β-d-glucopyranosyl-(1→3)]-β-d-galactopyranoside (4); japonicoside B (5); and japonicoside C (6). All six compounds showed cytotoxic activity against SMMC-7712, Bel-7402, A549, H460, and K562 human cancer cells.

【 授权许可】

Unknown