Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis

Molecules

Yuze Li²  Xin Wang¹  Hao He³  Dongdong Zhang²  Yi Jiang²  Xinjie Yang²  Fei Wang²  Zhishu Tang²  Xiaomei Song²  Zhenggang Yue² 

[1] The First Hospital of Xi’an, Xi’an 710002, China; E-Mail:;Shaanxi Collaborative Innovation Center of Chinese Medicinal Resource Industrialization, Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China; E-Mails:;School of Pharmaceutical Sciences, Xi’an Medical University, Xi’an 710021, China; E-Mail:

关键词: Tupistra chinensis;    steroidal saponins;    structure identification;    cytotoxic activity;   

DOI  :  10.3390/molecules200813659

来源: mdpi

【 摘 要 】

Two new furostanol saponins 1–2 and a new spirostanol saponin 3 were isolated together with two known furostanol saponins 4–5 from the roots and rhizomes of Tupistra chinensis. Their structures were characterized as 1β,2β,3β,4β,5β,26-hexahydroxyfurost-20(22),25(27)-dien-5,26-O-β-d-glucopyranoside (1), 1β,2β,3β,4β,5β,6β,7α,23ξ,26-nona-hydroxyfurost-20(22),25(27)-dien-26-O-β-d-glucopyranoside (2), (20S,22R)-spirost-25 (27)-en-1β,3β,5β-trihydroxy-1-O-β-d-xyloside (3), tupisteroide B (4) and 5β-furost-Δ²⁵⁽²⁷⁾-en-1β,2β,3β,4β,5β,7α,22ξ,26-octahydroxy-6-one-26-O-β-d-glucopyranoside (5), respectively, by extensive use of spectroscopic techniques and chemical evidence. Additionally, the in vitro cytotoxic activity of 1–4 was evaluated on human A549 and H1299 tumor cell lines, and compound 3 exhibited cytotoxicity against A549 cells (IC₅₀ 86.63 ± 2.33 μmol·L⁻¹) and H1299 cells (IC₅₀ 88.21 ± 1.34 μmol·L⁻¹).

【 授权许可】

CC BY   
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