Phenolic Compounds from the Flowers of Bombax malabaricum and Their Antioxidant and Antiviral Activities

Molecules

Yu-Bo Zhang²  Peng Wu²  Xiao-Li Zhang²  Chao Xia²  Guo-Qiang Li²  Wen-Cai Ye²  Guo-Cai Wang²  Yao-Lan Li²  Luis Cisneros-Zevallos¹ 

[1] Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China;;Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China; E-Mails:

关键词: Bombax malabaricum;    phenolic compounds;    structure identification;    antiviral activity;    antioxidant activity;   

DOI  :  10.3390/molecules201119660

来源: mdpi

【 摘 要 】

Three new phenolic compounds 1–3 and twenty known ones 4–23 were isolated from the flowers of Bombax malabaricum. Their chemical structures were elucidated by spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR) and chemical reactions. The antioxidant capacities of the isolated compounds were tested using FRAP and DPPH radical-scavenging assays, and compounds 4, 6, 8, 12, as well as the new compound 2, exhibited stronger antioxidant activities than ascorbic acid. Furthermore, all of compounds were tested for their antiviral activities against RSV by the CPE reduction assay and plaque reduction assay. Compounds 4, 10, 12 possess in vitro antiviral activities, and compound 10 exhibits potent anti-RSV effects, comparable to the positive control ribavirin.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.