High-frequency electroacupuncture evidently reinforces hippocampal synaptic transmission in Alzheimer′s disease rats

Neural Regeneration Research

关键词: nerve regeneration;    Alzheimer′s disease;    frequency;    electroacupuncture;    long-term potentiation;    long-term depression;    learning and memory;    Baihui (DU20);    Shenshu (BL23);    neural regeneration;   

DOI  :  10.4103/1673-5374.182708

来源: DOAJ

【 摘 要 】

The frequency range of electroacupuncture in treatment of Alzheimer′s disease in rats is commonly 2-5 Hz (low frequency) and 50-100 Hz (high frequency). We established a rat model of Alzheimer′s disease by injecting ß-amyloid 1-42 (Aß1-42 ) into the bilateral hippocampal dentate gyrus to verify which frequency may be better suited in treatment. Electroacupuncture at 2 Hz or 50 Hz was used to stimulate Baihui (DU20) and Shenshu (BL23) acupoints. The water maze test and electrophysiological studies demonstrated that spatial memory ability was apparently improved, and the ranges of long-term potentiation and long-term depression were increased in Alzheimer′s disease rats after electroacupuncture treatment. Moreover, the effects of electroacupuncture at 50 Hz were better than that at 2 Hz. These findings suggest that high-frequency electroacupuncture may enhance hippocampal synaptic transmission and potentially improve memory disorders in Alzheimer′s disease rats.

【 授权许可】

Unknown