Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People

Nutrients

Miquel Martorell¹  Emma Argelich¹  JosepA. Tur¹  Antoni Sureda¹  Xavier Capó¹  Cristina Bouzas²  Sandra Carreres³  Carla Busquets-Cortés³  Antoni Pons³  Mariadel Mar Bibiloni³  MiguelD. Ferrer³ 

[1] Laboratory of Physical Activity Science, University of Balearic Islands, 07122, Palma de Mallorca, Spain;Departamento de Nutrición y Dietética, Facultad de Farmacia, Universidad de Concepción, 4070386 Concepción, Chile;;Research Group on Community Nutrition and Oxidative Stress &

关键词: active lifestyle;    antioxidants;    daily habits;    elderly;    healthy aging;    mitochondria;    PBMCs;    ROS;   

DOI  :  10.3390/nu10101555

来源: DOAJ

【 摘 要 】

Regular physical activity prescription is a key point for healthy aging and chronic disease management and prevention. Our aim was to evaluate the antioxidant defense system and the mitochondrial status in peripheral blood mononuclear cells (PBMCs) and the level of oxidative damage in plasma in active, intermediate and inactive elderly. In total, 127 healthy men and women >55 years old participated in the study and were classified according on their level of declared physical activity. A more active lifestyle was accompanied by lower weight, fat mass and body mass index when compared to a more sedentary life-style. Active participants exhibited lower circulating PBMCs than inactive peers. Participants who reported higher levels of exercise had increased antioxidant protein levels when compared to more sedentary partakers. Carbonylated protein levels exhibited similar behavior, accompanied by a significant raise in expression of cytochrome c oxidase subunit IV in PBMCs. No significant changes were found in the activities of antioxidant enzymes and in the expression of structural (MitND5) and mitochondrial dynamic-related (PGC1α and Mitofusins1/2.) proteins. Active lifestyle and daily activities exert beneficial effects on body composition and it enhances the antioxidant defenses and oxidative metabolism capabilities in PBMCs from healthy elderly.

【 授权许可】

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