Antibacterial Activity and Drug Loading of Moxifloxacin-Loaded Poly(Vinyl Alcohol)/Chitosan Electrospun Nanofibers

Frontiers in Materials

Xiu-Hong Zhou¹  Qi Liu²  Wen-Chong Ouyang²  Zheng-Wei Wu²  Tao Jin² 

[1] Anhui Academy of Medical Sciences, Hefei, China;School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, China;

关键词: nanofiber;    antibacterial;    electrospinning;    moxifloxacin;    poly(vinyl alcohol);    chitosan;   

DOI  :  10.3389/fmats.2021.643428

来源: DOAJ

【 摘 要 】

In this study, nanofibers with different ratios of poly(vinyl alcohol) and chitosan incorporated with moxifloxacin hydrochloride (MH/PVA/CS) were fabricated through the blending electrospinning, and the morphological features were tested using scanning electron microscopy (SEM). Further characterization of the new nanofiber was accomplished by Thermogravimetric analysis (TG), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). Antibacterial activity of the MH-loaded nanofibers at different drug loading were tested and compared with the blank group. Experimental results show that the MH/PVA/CS nanofibers exhibited the good antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa due to the MH incorporation. Compared with blank nanofibers, MH/PVA/CS nanofibers have significantly better antibacterial properties, and different proportions of PVA and CS have a certain effect on the antibacterial activity of nanofibers. The conclusions in this paper show that MH/PVA/CS composite nanofibers may have great potential in antibacterial materials.

【 授权许可】

Unknown