Disparities in Functional Outcome After Intracerebral Hemorrhage Among Asians and Pacific Islanders

Frontiers in Neurology

Todd B. Seto¹  Kazuma Nakagawa¹  Marjorie K. L. M. Mau²  Sage L. King³ 

[1] Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States;Department of Native Hawaiian Health, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, United States;The Queen’s Medical Center, Honolulu, HI, United States;

关键词: race;    functional outcome;    intracerebral hemorrhage;   

DOI  :  10.3389/fneur.2018.00186

来源: DOAJ

【 摘 要 】

BackgroundDisparities in outcome after intracerebral hemorrhage (ICH) among Asians, Native Hawaiians, and other Pacific Islanders (NHOPI) have been inadequately studied. We sought to assess differences in functional outcome between Asians and NHOPI after ICH.MethodsA multiracial prospective cohort study of ICH patients was conducted from 2011 to 2016 at a tertiary center in Honolulu, HI, USA to assess racial disparities in outcome after ICH. Favorable outcome was defined as 3-month modified Rankin Scale (mRS) score ≤2. Patients with no available 3-month functional outcome, race other than Asians and NHOPI, and baseline mRS > 0 were excluded. Multivariable analyses using logistic regression were performed to assess the impact of race on favorable outcome after adjusting for the ICH Score, early do-not-resuscitate (DNR) order and dementia/cognitive impairment.ResultsA total of 220 patients (161 Asians, 59 NHOPI) were studied. Overall, 65 (29.5%) achieved favorable outcome at 3 months. NHOPI were younger than Asians (p < 0.0001) and had higher prevalence of diabetes (p = 0.007), obesity (p < 0.0001), and lower prevalence of dementia/cognitive impairment (p = 0.02), early DNR order (p = 0.0004), and advance directive presence (p = 0.0005). NHOPI race was a predictor of favorable outcome in the unadjusted model [odds ratio (OR) 2.47, 95% confidence interval (CI): 1.32–4.62] and after adjusting for the ICH Score (OR 2.30, 95% CI: 1.06–4.97) but not in the final model (OR 2.04, 95% CI: 0.94–4.42). In the final model, the ICH Score was the only independent negative predictor of outcome (OR 0.26, 95% CI: 0.17–0.41 per point).ConclusionNHOPI are more likely to achieve favorable functional outcome after ICH compared with Asians even after controlling for ICH severity. However, this association was attenuated by the DNR and dementia/cognitive impairment status.

【 授权许可】

Unknown