Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage

Journal of Clinical Medicine

Francesc Pujadas¹  Pere Cardona Portela²  Maite Martínez-Zabaleta³  Soledad Pérez-Sánchez⁴  Silvia Tur⁵  Alex Rovira⁶  Carla Vert⁶  M. Mar Freijo⁷  Mar Hernández-Guillamon⁸  Anna Penalba⁸  Jesús Pizarro⁸  Paula Marazuela⁸  Joan Montaner⁸  Júlia Faura⁸  Pilar Delgado⁸  Anna Bonaterra-Pastra⁸  Juan F. Arenillas⁹  Rocío Vera^1,10  David Rodríguez-Luna^1,11  Olalla Pancorbo^1,11  Lucia Lebrato-Hernández^1,12 

[1] Dementia Unit, Neurology Department, Vall d’Hebron Hospital, 08035 Barcelona, Spain;Department of Neurology, Bellvitge University Hospital, L’Hospitalet de Llobregat, 08907 Barcelona, Spain;Department of Neurology, Donostia University Hospital, 20080 San Sebastián, Spain;Department of Neurology, Virgen Macarena University Hospital, 41009 Sevilla, Spain;Neurology, Son Espases University Hospital, 07120 Balearic Islands, Spain;Neuroradiology, Department of Radiology, Vall d’Hebron Hospital, 08035 Barcelona, Spain;Neurovascular Group, Biocruces Health Research Institute, 48903 Barakaldo, Spain;Neurovascular Research Laboratory, Vall d’Hebron Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain;Stroke Program, Department of Neurology, Hospital Clínico Universitario, 47003 Valladolid, Spain;Stroke Unit, Department of Neurology, Ramon y Cajal University Hospital, 28034 Madrid, Spain;Stroke Unit, Department of Neurology, Vall d’Hebron Hospital, 08035 Barcelona, Spain;Stroke Unit, Virgen del Rocío University Hospital, 41013 Sevilla, Spain;

关键词: aquaporin 4;    cerebral amyloid angiopathy;    intracerebral hemorrhage;    magnetic resonance imaging markers;    functional outcome;   

DOI  :  10.3390/jcm10050989

来源: DOAJ

【 摘 要 】

Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA–ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 ± 18.6 months) and long-term (38.5 ± 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as ≥2 lobar ICHs and ≥5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.

【 授权许可】

Unknown