SWnet: a deep learning model for drug response prediction from cancer genomic signatures and compound chemical structures

BMC Bioinformatics

Penglei Wang¹  Dahong Qian¹  Zhaorui Zuo¹  Li Tian²  Hui Ge²  Xiaowei Chen² 

[1]Institute of Medical Robotics, Shanghai Jiao Tong University

[2]Novartis Institutes for Biomedical Research

关键词: Deep learning;    Genomics;    Cheminformatics;    Drug response;   

DOI  :  10.1186/s12859-021-04352-9

来源: DOAJ

【 摘 要 】

Abstract Background One of the major challenges in precision medicine is accurate prediction of individual patient’s response to drugs. A great number of computational methods have been developed to predict compounds activity using genomic profiles or chemical structures, but more exploration is yet to be done to combine genetic mutation, gene expression, and cheminformatics in one machine learning model. Results We presented here a novel deep-learning model that integrates gene expression, genetic mutation, and chemical structure of compounds in a multi-task convolutional architecture. We applied our model to the Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE) datasets. We selected relevant cancer-related genes based on oncology genetics database and L1000 landmark genes, and used their expression and mutations as genomic features in model training. We obtain the cheminformatics features for compounds from PubChem or ChEMBL. Our finding is that combining gene expression, genetic mutation, and cheminformatics features greatly enhances the predictive performance. Conclusion We implemented an extended Graph Neural Network for molecular graphs and Convolutional Neural Network for gene features. With the employment of multi-tasking and self-attention functions to monitor the similarity between compounds, our model outperforms recently published methods using the same training and testing datasets.

【 授权许可】

Unknown