The Vav GEF Family: An Evolutionary and Functional Perspective

Cells

XoséR. Bustelo¹  Sonia Rodríguez-Fdez¹ 

[1] Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC) and University of Salamanca, Campus Unamuno, E37007 Salamanca, Spain;

关键词: Rho GTPases;    Dbl-homology;    guanosine diphosphate to guanosine triphosphate exchange factors;    protein tyrosine kinases;    signaling;    evolution;    phosphorylation;    tyrosine;    animal models;   

DOI  :  10.3390/cells8050465

来源: DOAJ

【 摘 要 】

Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the genomes of many species has revealed that this protein family originated in choanozoans, a group of unicellular organisms from which animal metazoans are believed to have originated from. Since then, the Vav family underwent expansions and reductions in its members during the evolutionary transitions that originated the agnates, chondrichthyes, some teleost fish, and some neoaves. Exotic members of the family harboring atypical structural domains can be also found in some invertebrate species. In this review, we will provide a phylogenetic perspective of the evolution of the Vav family. We will also pay attention to the structure, signaling properties, regulatory layers, and functions of Vav proteins in both invertebrate and vertebrate species.

【 授权许可】

Unknown