The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases

Toxins

Sara Travaglione¹  Stefano Loizzo¹  Giulia Ballan¹  Carla Fiorentini¹ 

[1]Department of Therapeutic Research and Medicines Evaluation, Superior Health Institute, viale Regina Elena 299, Rome 00161, Italy

关键词: CNF1;    actin cytoskeleton;    synaptic plasticity;    Rho GTPases;   

DOI  :  10.3390/toxins6010270

来源: mdpi

【 摘 要 】

The Cytotoxic Necrotizing Factor 1 (CNF1), a protein toxin from pathogenic E. coli, modulates the Rho GTPases, thus, directing the organization of the actin cytoskeleton. In the nervous system, the Rho GTPases play a key role in several processes, controlling the morphogenesis of dendritic spines and synaptic plasticity in brain tissues. This review is focused on the peculiar property of CNF1 to enhance brain plasticity in in vivo animal models of central nervous system (CNS) diseases, and on its possible application in therapy.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.