The Yin and Yang of Autosomal Recessive Primary Microcephaly Genes: Insights from Neurogenesis and Carcinogenesis

International Journal of Molecular Sciences

Yiqiang Zhi¹  Xiaokun Zhou¹  Jurui Yu¹  Dan Xu¹ 

[1] College of Biological Science and Engineering, Institute of Life Sciences, Fuzhou University, Fuzhou 350108, China;

关键词: autosomal recessive primary microcephaly;    neurogenesis;    carcinogenesis;    centrosome;    cell cycle;    cell apoptosis;   

DOI  :  10.3390/ijms21051691

来源: DOAJ

【 摘 要 】

The stem cells of neurogenesis and carcinogenesis share many properties, including proliferative rate, an extensive replicative potential, the potential to generate different cell types of a given tissue, and an ability to independently migrate to a damaged area. This is also evidenced by the common molecular principles regulating key processes associated with cell division and apoptosis. Autosomal recessive primary microcephaly (MCPH) is a neurogenic mitotic disorder that is characterized by decreased brain size and mental retardation. Until now, a total of 25 genes have been identified that are known to be associated with MCPH. The inactivation (yin) of most MCPH genes leads to neurogenesis defects, while the upregulation (yang) of some MCPH genes is associated with different kinds of carcinogenesis. Here, we try to summarize the roles of MCPH genes in these two diseases and explore the underlying mechanisms, which will help us to explore new, attractive approaches to targeting tumor cells that are resistant to the current therapies.

【 授权许可】

Unknown