Therapeutic drug monitoring and methods of quantitation for carbamazepine

Journal of Mind and Medical Sciences

Ana M. Vlasceanu¹  Daniela L. Baconi¹  Cristian Tuchila¹  Miriana Stan¹  Cristina D. Pirvu¹  Denisa O. Balalau²  Cristian Balalau³ 

[1] Carol Davila University of Medicine and Pharmacy, Department of Toxicology, Bucharest, Romania;Carol Davila University, Bucur Maternity Hospital, Bucharest, Romania;Carol Davila University, St. Pantelimon Hospital, Bucharest, Romania;

关键词: carbamazepine;    therapeutic drug monitoring;    bioanalytical method;    validation;    epilepsy;   

DOI  :  10.22543/7674.42.P100114

来源: DOAJ

【 摘 要 】

Carbamazepine is an early anticonvulsant still used today in the treatment of several forms of epilepsy. An active metabolite in the human body contributes to its pharmacological effect. Carbamazepine metabolism has high inter-individual variability, such that it is relatively difficult to establish a direct link between dose and concentration, or between concentration and pharmacological effect. Carbamazepine is thus a good candidate for therapeutic drug monitoring (TDM). Good UV specific absorbance and high plasmatic concentrations allow for the use of UV detection, which is often more accessible than other methods of detection. This paper presents several methods used for the detection of carbamazepine in plasma, methods that are capable of detecting drug and metabolites at adequate levels/ acceptance criteria. These methods have possible application not only in pharmacokinetic, bioequivalence, and permeability studies, but also in the therapeutic drug monitoring of carbamazepine.

【 授权许可】

Unknown