Fatal invasive aspergillosis caused by Aspergillus niger after bilateral lung transplantation

Medical Mycology Case Reports

Yves Castier¹  Sandrine Houzé²  Laurent Massias³  Claire Chabut³  Olivier Brugière⁴  Hervé Mal⁴  Sylvain Jean-Baptiste⁵  Philippe Montravers⁵  Enora Atchade⁵ 

[1] Chirurgie thoracique et vasculaire, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, Paris 75018, France;Laboratoire de Parasitologie-Mycologie, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, Paris 75018, France;Pharmacologie et toxicologie, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, Paris 75018, France;Pneumologie B, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, Paris 75018, France;Réanimation chirurgicale, Hôpital Bichat Claude Bernard, 46 rue Henri Huchard, Paris 75018, France;

关键词: Invasive aspergillosis;    Aspergillus niger;    Lung transplantation;    Voriconazole;    Massive hemoptysis;   

DOI  :  10.1016/j.mmcr.2017.05.002

来源: DOAJ

【 摘 要 】

Aspergillus niger is usually considered to be a low virulence fungus, not commonly reported to cause invasive infections. Invasive pulmonary aspergillosis due to Aspergillus niger was diagnosed in a 43-year-old woman following bilateral lung transplantation. Intravenous voriconazole failed to control progression of the disease. Despite salvage therapy with a combination of voriconazole and caspofungin for 23 days, the patient developed massive hemoptysis leading to death. The authors report the clinical features and treatment of this case.

【 授权许可】

Unknown