The dysbiosis signature of Fusobacterium nucleatum in colorectal cancer-cause or consequences? A systematic review

Cancer Cell International

Laleh Rafiee¹  Shaghayegh Haghjooy Javanmard¹  Maryam Ranjbar¹  Mostafa Manian²  Rasoul Salehi³  Gordon A. Ferns⁴  Majid Ghayour-Mobarhan⁵  Habibollah Faraji⁶  Sima jafarpor⁷  Reza Nedaeinia⁷ 

[1] Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences;Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences;Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences;Division of Medical Education, Brighton and Sussex Medical School;Metabolic Syndrome Research Center, Mashhad University of Medical Sciences;Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences;Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences;

关键词: Colorectal cancer;    Dysbiosis signature;    F. nucleatum;    Gut microbiota;   

DOI  :  10.1186/s12935-021-01886-z

来源: DOAJ

【 摘 要 】

Abstract Colorectal cancer (CRC) is the third most common cause of cancer globally and the fourth attributable cause of mortality and morbidity due to cancer. An emerging factor contributing to CRC is the gut microbiota and the cellular changes associated with it. Further insights on this may help in the prevention, diagnosis and new therapeutic approaches to colorectal cancer. In most cases of CRC, genetic factors appear to contribute less to its aetiology than environmental and epigenetic factors; therefore, it may be important to investigate these environmental factors, their effects, and the mechanisms that may contribute to this cancer. The gut microbiota has recently been highlighted as a potential risk factor that may affect the structural components of the tumor microenvironment, as well as free radical and enzymatic metabolites directly, or indirectly. Many studies have reported changes in the gut microbiota of patients with colorectal cancer. What is controversial is whether the cancer is the cause or consequence of the change in the microbiota. There is strong evidence supporting both possibilities. The presence of Fusobacterium nucleatum in human colorectal specimens has been demonstrated by RNA-sequencing. F. nucleatum has been shown to express high levels of virulence factors such as FadA, Fap2 and MORN2 proteins. Our review of the published data suggest that F. nucleatum may be a prognostic biomarker of CRC risk, and hence raises the potential of antibiotic treatment of F. nucleatum for the prevention of CRC.

【 授权许可】

Unknown