The endocrine vitamin D system in the gut

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:453

Article

Barbachano, Antonio¹  Fernandez-Barral, Asuncion¹  Ferrer-Mayorga, Gemma¹  Costales-Carrera, Alba¹  Jesus Larriba, Maria¹  Munoz, Alberto¹ 

[1] Univ Autonoma Madrid, Consejo Super Invest Cientif, Inst Invest Biomed Alberto Sols, E-28029 Madrid, Spain

关键词: Vitamin D;    Gut homeostasis;    Inflammatory bowel diseases;    Gut microbiota;    Colorectal cancer;   

DOI  :  10.1016/j.mce.2016.11.028

来源: Elsevier

【 摘 要 】

The active vitamin D metabolite 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) has important regulatory actions in the gut through endocrine and probably also intracrine, autocrine and paracrine mechanisms. By activating the vitamin D receptor (VDR), which is expressed at a high level in the small intestine and colon, 1,25(OH)(2)D-3 regulates numerous genes that control gut physiology and homeostasis. 1,25(OH)(2)D-3 is a major responsible for epithelial barrier function and calcium and phosphate absorption, and the host's defense against pathogens and the inflammatory response by several types of secretory and immune cells. Moreover, recent data suggest that 1,25(OH)(2)D-3 has a regulatory effect on the gut microbiota and stromal fibroblasts. Many studies have linked vitamin D deficiency to inflammatory bowel diseases (ulcerative colitis and Crohn's disease) and to an increased risk of colorectal cancer, and the possible use of VDR agonists to prevent or treat these diseases is receiving increasing interest. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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