Annals of Hepatology | |
Is there an association between commonly employed biomarkers of liver fibrosis and liver stiffness in the general population? | |
Lucia Napoli1 Alberto Borghi1 Francesco Giuseppe Foschi1 Federica Mirici1 Anna Chiara Dall’Aglio1 Vittoria Bevilacqua1 Giorgio Ercolani1 Fabio Conti1 Pierluigi Giacomoni2 Marco Domenicali3 Alessandro Cucchetti3 Mauro Giuffrè4 Andrea Casadei Gardini5 Amalia Gastaldelli6 Giorgio Bedogni7 Stefano Bellentani7 Claudio Tiribelli7 | |
[1] Department of Internal Medicine, Ospedale di Faenza, AUSL Romagna, Italy;Department of Internal Medicine, Ospedale di Lugo, AUSL Romagna, Italy;Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy;Department of Oncology and Hematology, Division of Oncology, University of Modena and Reggio Emilia, Modena, Italy;Institute of Clinical Physiology, National Research Council, Pisa, Italy;Italian Liver Foundation, Basovizza, Trieste, Italy; | |
关键词: Epidemiology; Cross-sectional study; Chronic liver disease; Liver fibrosis; Elasticity imaging technique; Biomarkers; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
Introduction and objectives: Surrogate biomarkers of liver fibrosis developed in tertiary care are increasingly used in general populations. We evaluated the association between liver stiffness (LS) and five continuous (AST/ALT, APRI, Forns Index, FIB-4, GGT) and two discrete biomarkers (BARD, BAAT) in a general population. Patients and methods: 636 (29%) of the 2159 citizens of the Bagnacavallo Study had LS measured by transient elastography. Using linear regression with univariate multiple imputation, we evaluated the association of LS with the above biomarkers in the total sample of 2159 citizens. Results: The mean change of LS between the 5th and 95th internal percentile of any continuous biomarker was ≤1 kPa. The mean change of LS between scores 0 and 3 of BARD and scores 0 and ≥3 of BAAT was >1 kPa but of doubtful clinical relevance. Conclusion: We found a modest association between LS and seven biomarkers of liver fibrosis in a general population.
【 授权许可】
Unknown