Is there an association between commonly employed biomarkers of liver fibrosis and liver stiffness in the general population?

Annals of Hepatology

Lucia Napoli¹  Alberto Borghi¹  Francesco Giuseppe Foschi¹  Federica Mirici¹  Anna Chiara Dall’Aglio¹  Vittoria Bevilacqua¹  Giorgio Ercolani¹  Fabio Conti¹  Pierluigi Giacomoni²  Marco Domenicali³  Alessandro Cucchetti³  Mauro Giuffrè⁴  Andrea Casadei Gardini⁵  Amalia Gastaldelli⁶  Giorgio Bedogni⁷  Stefano Bellentani⁷  Claudio Tiribelli⁷ 

[1] Department of Internal Medicine, Ospedale di Faenza, AUSL Romagna, Italy;Department of Internal Medicine, Ospedale di Lugo, AUSL Romagna, Italy;Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy;Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy;Department of Oncology and Hematology, Division of Oncology, University of Modena and Reggio Emilia, Modena, Italy;Institute of Clinical Physiology, National Research Council, Pisa, Italy;Italian Liver Foundation, Basovizza, Trieste, Italy;

关键词: Epidemiology;    Cross-sectional study;    Chronic liver disease;    Liver fibrosis;    Elasticity imaging technique;    Biomarkers;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction and objectives: Surrogate biomarkers of liver fibrosis developed in tertiary care are increasingly used in general populations. We evaluated the association between liver stiffness (LS) and five continuous (AST/ALT, APRI, Forns Index, FIB-4, GGT) and two discrete biomarkers (BARD, BAAT) in a general population. Patients and methods: 636 (29%) of the 2159 citizens of the Bagnacavallo Study had LS measured by transient elastography. Using linear regression with univariate multiple imputation, we evaluated the association of LS with the above biomarkers in the total sample of 2159 citizens. Results: The mean change of LS between the 5th and 95th internal percentile of any continuous biomarker was ≤1 kPa. The mean change of LS between scores 0 and 3 of BARD and scores 0 and ≥3 of BAAT was >1 kPa but of doubtful clinical relevance. Conclusion: We found a modest association between LS and seven biomarkers of liver fibrosis in a general population.

【 授权许可】

Unknown