Senescence in chronic liver disease: Is the future in aging?

JOURNAL OF HEPATOLOGY

卷:65

Review

Arayinthan, Aloysious D.^1,4,5  Alexander, Graeme J. M.^2,3 

[1] Univ Toronto, Dept Med, Toronto, ON, Canada

[2] Royal Free Trust, UCL Inst Liver & Digest Hlth, London, England

[3] Univ Cambridge, Dept Med, Cambridge, England

[4] Univ Nottingham, Nottingham Digest Dis Biomed Res Unit, NIHR, Nottingham, England

[5] Nottingham Univ Hosp NHS Trust, Nottingham, England

关键词: Cellular senescence;    Hepatocyte;    senescence;    Chronic liver disease;    Liver fibrosis;   

DOI  :  10.1016/j.jhep.2016.05.030

来源: Elsevier

【 摘 要 】

Cellular senescence is a fundamental, complex mechanism with an important protective role present from embryogenesis to late life across all species. It limits the proliferative potential of damaged cells thus protecting against malignant change, but at the expense of substantial alterations to the microenvironment and tissue homeostasis, driving inflammation, fibrosis and paradoxically, malignant disease if the process is sustained. Cellular senescence has attracted considerable recent interest with recognition of pathways linking aging, malignancy and insulin resistance and the current focus on therapeutic interventions to extend health-span. There are major implications for hepatology in the field of fibrosis and cancer, where cellular senescence of hepatocytes, cholangiocytes, stellate cells and immune cells has been implicated in chronic liver disease progression. This review focuses on cellular senescence in chronic liver disease and explores therapeutic opportunities. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free