Anticoagulant, anti-inflammatory, antiviral and antitumor properties of heparins

Акушерство, гинекология и репродукция

S. Shulman¹  J.-C. Gris²  K. E. Gotsiridze³  E. V. Slukhanchuk⁴  N. V. Pyatigorskaya⁵  V. O. Bitsadze⁵  S. V. Akinshina⁵  K. N. Grigoreva⁵  N. A. Makatsariya⁵  J. Kh. Khizroeva⁵  I. Elalamy⁵  A. S. Shkoda⁶  N. N. Babaeva⁷  M. V. Tretyakova⁸ 

[1] Hospital Tenon;Medicine Sorbonne University;Chachava Clinic;Petrovsky National Research Centre of Surgery;Sechenov University;Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department;«Altamed+» LLC;«Medical Center» LLC;

关键词: heparin;    anticoagulants;    metastases;    inflammation;    covid-19;   

DOI  :  10.17749/2313-7347/ob.gyn.rep.2021.216

来源: DOAJ

【 摘 要 】

Our knowledge regarding chemical structure and properties of heparin and its derivatives, including biological properties in blood plasma, on the cell surface and while interacting with receptors, has been progressively growing. New insights are followed by the expansion of therapeutic opportunities and indications for the use of heparins. There are prerequisites for the creation of new generation drugs with modified properties that reduce a bleeding risk while applied for a non-anticoagulant goal. The non-anticoagulant heparin properties allow to consider it as a candidate for pathogenetic treatment of patients with COVID-19. This review focuses on the anticoagulant and non-anticoagulant heparin properties as well as the underlying molecular mechanisms.

【 授权许可】

Unknown