The influence of grafted heparin on chitosan/poly (ethylene glycol) blend membrane and it's application for creatinine and urea transport

13th Joint Conference on Chemistry

Lusiana, Retno Ariadi^1 ; Putri, Amalia^1 ; Suseno, Ahmad^1 ; Djunaedi, Muhammad Cholid^1 ; Gunawan^1

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Diponegoro, Semarang

50275, Indonesia^1

关键词: Grafting reactions;    heparin;    Membrane transport;    Modified chitosan;    Optimum concentration;    Positive charges;    Transport membranes;    Transport process;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/509/1/012121/pdf
DOI  :  10.1088/1757-899X/509/1/012121

来源: IOP

【 摘 要 】

Modification of membrane using grafting reaction between chitosan and heparin showed the functional group on grafting agent reduced the positive charge on the membran surface and increased the active carrier groups which lead to increasing the membrane transport. The optimum concentration of heparin modified chitosan was determined by creatinine and urea transport studies. With the optimum concentration, the membrane was used for the transports of creatinine, urea and as well as a mixture of 5 species (creatinine, urea, Vitamine B12, albumin, and mineral salts). Characterization of the membrane was done using FT-IR Spectrophotometer and SEM. The results showed that the best concentration of heparin at 100 iu in the percent transports of creatinine and urea were 31.83% and 41.99%, respectively, for 6 hours of transport times. The other species in the transport membrane were proposed to disturb the creatinine permeation through the membrane. Addition of polyethyleneglycol (PEG) also increased the mechanical and porosity of the membrane in transport process.