Progress update from the hippocampal subfields group

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Song‐Lin Ding¹  Katrin Amunts²  Attila Keresztes³  Yee Lee Shing³  Markus Werkle‐Bergner³  Elliott G. Johnson⁴  Karen M. Rodrigue⁵  Kristen M. Kennedy⁵  Robert S.C. Amaral⁶  M. Mallar Chakravarty⁶  David Berron⁷  Martina Bocchetta⁸  Yushan Huang⁹  Andrew R. Bender^1,10  Craig E.L. Stark^1,11  Renaud La Joie^1,12  Lorenzo Pasquini^1,12  Lei Wang^1,13  Arnold Bakker^1,14  Joshua K. Lee^1,15  Nanthia A. Suthana^1,16  Marina Boccardi^1,17  Elizabeth M. Mulligan^1,18  Valerie A. Carr^1,19  Daniela J. Palombo^2,20  Margaret L. Schlichting^2,21  Naftali Raz^2,22  Qijing Yu^2,22  Ana M. Daugherty^2,22  Noa Ofen^2,22  Prabesh Kanel^2,23  Jean C. Augustinack^2,24  Susanne G. Mueller^2,25  Paul A. Yushkevich^2,26  Laura E.M. Wisse^2,26  Trevor A. Steve^2,27  John Pluta^2,28  Olga Kedo^2,29  Ricardo Insausti^3,30  Mirjam I. Geerlings^3,31  Ulman Lindenberger^3,32  Jordan DeKraker^3,33  Alison C. Burggren^3,34  Hippocampal Subfields Group^3,35  Rosanna K. Olsen^3,35  Robin deFlores^3,36  Gaël Chételat^3,36 

[1] Allen Institute for Brain ScienceSeattleWAUSA;C. and O. Vogt Institute for Brain ResearchMedical FacultyUniversity Hospital DüsseldorfDüsseldorfGermany;Center for Lifespan Psychology, Max Planck Institute for Human DevelopmentBerlinGermany;Center for Mind and Brain, University of CaliforniaDavisCAUSA;Center for Vital LongevityBehavioral and Brain ScienceThe University of Texas at DallasDallasTXUSA;Cerebral Imaging Centre, Douglas Hospital Mental Health University InstituteVerdunQuebecCanada;Clinical Memory Research UnitDepartment of Clinical Sciences MalmöLund UniversityLundSweden;Dementia Research CentreDepartment of Neurodegenerative DiseaseUniversity College LondonLondonUnited Kingdom;Department of Biomedical EngineeringUniversity of AlbertaEdmontonAlbertaCanada;Department of Epidemiology and BiostatisticsMichigan State UniversityEast LansingMIUSA;Department of Neurobiology and BehaviorCenter for Learning and Memory, University of CaliforniaIrvineCAUSA;Department of NeurologyMemory and Aging Center, University of CaliforniaSan FranciscoCAUSA;Department of Psychiatry and Behavioral Sciences and Department RadiologyNorthwestern University Feinberg School of MedicineChicagoILUSA;Department of Psychiatry and Behavioral SciencesJohns Hopkins University School of MedicineBaltimoreMDUSA;Department of Psychiatry and Behavioral SciencesUniversity of California Davis School of MedicineDavisCAUSA;Department of Psychiatry and Biobehavioral Sciences, Department of NeurosurgeryUniversity of CaliforniaLos AngelesCAUSA;Department of PsychiatryUniversity of GenevaGenevaSwitzerland;Department of PsychologyFlorida State UniversityTallahasseeFLUSA;Department of PsychologySan Jose State UniversitySan JoseCAUSA;Department of PsychologyUniversity of British ColumbiaVancouverBritish ColumbiaCanada;Department of PsychologyUniversity of TorontoTorontoOntarioCanada;Department of PsychologyWayne State UniversityDetroitMIUSA;Department of Radiology at the University of MichiganAnn ArborMIUSA;Department of RadiologyHarvard Medical SchoolCharlestownMAUSA;Department of RadiologyUniversity of CaliforniaSan FranciscoCAUSA;Department of RadiologyUniversity of PennsylvaniaPhiladelphiaPAUSA;Division of Neurology, Department of MedicineUniversity of AlbertaEdmontonAlbertaCanada;Division of Translational Medicine and GenomicsUniversity of PennsylvaniaPhiladelphiaPAUSA;Heinrich Heine University DüsseldorfDüsseldorfGermany;Human Neuroanatomy Laboratory, University of Castilla‐La ManchaAlbaceteSpain;Julius Center for Health Sciences and Primary Care, University Medical Center UtrechtUtrechtThe Netherlands;Research Centre for Natural Sciences, Hungarian Academy of SciencesBudapestHungary;Robarts Research Institute, Brain and Mind Institute, University of Western OntarioLondonOntarioCanada;Robert and Beverly Lewis Center for Neuroimaging, University of OregonEugeneORUSA;Rotman Research Institute, Baycrest Health SciencesTorontoOntarioCanada;Université Normandie, Université de Caen‐NormandieCaenFrance;

关键词: Hippocampus;    Volumetry;    Human;    Neuroimaging;    Structural imaging;    Neuroanatomy;   

DOI  :  10.1016/j.dadm.2019.04.001

来源: DOAJ

【 摘 要 】

Abstract Introduction Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods Our international working group, funded by the EU Joint Programme–Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.

【 授权许可】

Unknown