Design of Silicon Photonic Structures for Multi-Site, Multi-Spectral Optogenetics in the Deep Brain

IEEE Photonics Journal

Xing Sheng¹  Roya Nazempour¹  Qianyi Zhang¹  Changbo Liu² 

[1] Department of Electronic Engineering, Beijing National Research Center for Information Science and Technology, Center for Flexible Electronics Technology, Tsinghua University, Beijing, China;School of Materials Science and Engineering and Hangzhou Innovation Institute, Beihang University, Beijing, China;

关键词: Implantable device;    silicon photonics;    optogenetics;   

DOI  :  10.1109/JPHOT.2020.3039015

来源: DOAJ

【 摘 要 】

Micro- and nanoscale photonic structures and devices play important roles in the development of advanced biophotonic systems, in particular, implantable light sources for optogenetic stimulations. In this paper, we numerically investigate silicon (Si) photonics based microprobes that can achieve multi-site, multi-spectral optical excitation in the deep animal brain. On Si substrates, silicon nitride (Si₃N₄) based planar waveguides can deliver visible light in the deep tissue with low losses, and couple to grating emitters diffracting light in targeted brain regions. In our model, we combine near-field wave optic and far-field ray tracing simulations, showing that the designed photonic structures spectrally split blue, green and red photons into different locations in the tissue. Furthermore, by introducing dual grating components, photons at different wavelengths can be spatially separated at different depths. Therefore, these photonic probes can be used to selectively activate or inhibit specific neurons and nuclei, when expressing various corresponding light sensitive opsins. We anticipate that such device strategies can find wide applications in the design of advanced implantable photonic systems for neuroscience and neuroengineering.

【 授权许可】

Unknown