Prevalence of parkinsonism and Parkinson disease in urban and rural populations from Latin America: A community based study

The Lancet Regional Health. Americas

Ana Luisa Sosa¹  Matthew Prina²  Geeske Peeters³  Jorge J Llibre-Guerra⁴  Caroline Tanner⁴  Juan J. Llibre Rodriguez⁵  Daisy Acosta⁶  Juan C Llibre-Guerra⁷  Aquiles Salas⁸  Jorge Juncos⁹  Ivonne Z. Jimenez-Velazquez⁹  Ellen Ziegemeier^1,10  Adolfo Valvuerdi^1,11  Isaac Acosta^1,12  Mariella Guerra^1,13 

[1] Corresponding author: Jorge J Llibre Guerra, MD, MSc, Department of Neurology, Washington University School of Medicine in St.Louis, USA;Department of Neurology, National Institute of Neurology and Neurosurgery, La Habana, Cuba;Department of Neurology, Hospital del Mar, Barcelona, Spain;Department of Neurology, Washington University School of Medicine in St. Louis, USA;Department of Neurology, Weill Institute for Neurosciences, University of San Francisco, California, USA;Health Service and Population Research Department, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom;Instituto de la Memoria Depresion y Enfermedades de Riesgo IMEDER, Lima, Perú;Internal Medicine Department, Geriatrics Program, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico;Laboratory of the Dementias, National Institute of Neurology and Neurosurgery of Mexico, National Autonomous University of Mexico, Mexico City, Mexico;Medical University of Matanzas, Matanzas, Cuba;Medicine Department, Caracas University Hospital, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela;Radboud Institute of Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands;Universidad Nacional Pedro Henriquez Ureña (UNPHU), Internal Medicine Department, Geriatric Section, Santo Domingo, Dominican Republic;

关键词: Parkinsonism;    Parkinson's disease;    Prevalence;    Risk factors;    Latin America;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary:Background: Age and gender specific prevalence rates for parkinsonism and Parkinson's disease (PD) are important to guide research, clinical practice, and public health planning; however, prevalence estimates in Latin America (LatAm) are limited. We aimed to estimate the prevalence of parkinsonism and PD and examine related risk factors in a cohort of elderly individuals from Latin America (LatAm). Methods: Data from 11,613 adults (65+ years) who participated in a baseline assessment of the 10/66 study and lived in six LatAm countries were analyzed to estimate parkinsonism and PD prevalence. Crude and age-adjusted prevalence were determined by sex and country. Diagnosis of PD was established using the UK Parkinson's Disease Society Brain Bank's clinical criteria. Findings: In this cohort, the prevalence of parkinsonism was 8.0% (95% CI 7.6%–8.5%), and the prevalence of PD was 2.0% (95% CI 1.7%–2.3%). PD prevalence increased with age from 1.0 to 3.5 (65–69vs. 80 years or older, p < 0.001). Age-adjusted prevalence rates were lower for women than for men. No significant differences were found across countries, except for lower prevalence in urban areas of Peru. PD was positively associated with depression (adjusted prevalence ratio [aPR] 2.06, 95% CI 1.40–3.01, I2 = 56.0%), dementia (aPR 1.57, 95% CI 1.07- 2.32, I2 = 0.0%) and educational level (aPR 1.14, 95% CI 1.01– 1.29, I2 = 58.6%). Interpretation: The reported prevalence of PD in LatAm is similar to reports from high-income countries (HIC). A significant proportion of cases with PD did not have a previous diagnosis, nor did they seek any medical or neurological attention. These findings underscore the need to improve public health programs for populations currently undergoing rapid demographic aging and epidemiological transition. Funding: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

【 授权许可】

Unknown