Depression in Parkinson's disease: clinical-epidemiological correlates and comparison with a controlled group of non-parkinsonian geriatric patients

Revista Brasileira de Psiquiatria

Beatriz Azevedo Dos Anjos Godke Veiga²  Vanderci Borges²  Sonia Maria César De Azevedo Silva²  Fabrício De Oliveira Goulart²  Maysa Seabra Cendoroglo¹  Henrique Ballalai Ferraz² 

[1] ,Universidade Federal de São Paulo INeurology Course São Paulo SP ,Brazil

关键词: Parkinson's disease;    Depression;    Prevalence;    Patient selection;    Geriatrics;    Doença de Parkinson;    Depressão;    Prevalência;    Seleção de pacientes;    Geriatria;   

DOI  :  10.1590/S1516-44462009000100010

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate and compare the frequency and severity of major depression in patients with Parkinson's disease and in individuals older than 60 years without neurological, rheumatological and/or oncological comorbidities. METHOD: We studied 50 patients with Parkinson's disease older than 60 years and 50 geriatric patients. Subjects with scores of Mini Mental State Examination indicating cognitive impairment were excluded. We used Diagnostic Statistical Manual of Mental Diseases-IV criteria to diagnose major depression and the Hamilton Depression Scale and the Beck Depression Inventory to rate it. The Unified Parkinson's Disease Rating Scale part 3 and the Hoehn and Yahr Scale were used to evaluate the motor severity of Parkinson's disease. RESULTS: Major depression was found in 42% of Parkinson's disease patients and in 10% of the geriatric patients (p < 0.001). The scores of the Hamilton Depression Scale and the Beck Depression Inventory were higher in Parkinson's disease patients (p < 0.001). Depressed Parkinson's disease patients had longer duration of Parkinson's disease (p = 0.020) and higher scores on the Unified Parkinson's Disease Rating Scale part 3 (p = 0.029) and the Yahr Scale (p = 0.027). CONCLUSIONS: The frequency (42%) and severity of major depression were higher in Parkinson's disease patients. Longer duration of Parkinson's disease, higher scores on the Unified Parkinson's Disease Rating Scale part 3 and the Hoehn and Yahr Scale were significantly associated with major depression.

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