Preparation and Characterization of Electrospun Collagen Based Composites for Biomedical Applications

Materials

Stelian Vlad¹  Alexandra Bargan¹  Mioara Drobota¹  LuizaMadalina Gradinaru¹  Maria Butnaru¹  Magdalena Aflori¹  Marian Angheloiu² 

[1] Physics of Polymers and Polymeric Materials, “Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda, 41A, 700487 Iasi, Romania;Sanimed International IMPEX SRL, Sos. București Măgurele 70F, 051434 Bucharest, Romania;

关键词: collagen;    PET;    nanofibrous mats;    FTIR-ATR spectroscopy;    Dynamic Vapor Sorption (DVS);    cell growth;   

DOI  :  10.3390/ma13183961

来源: DOAJ

【 摘 要 】

Electrospinning is a widely used technology for obtaining nanofibers from synthetic and natural polymers. In this study, electrospun mats from collagen (C), polyethylene terephthalate (PET) and a blend of the two (C-PET) were prepared and stabilized through a cross-linking process. The aim of this research was to prepare and characterize the nanofiber structure by Fourier-transform infrared with attenuated total reflectance spectroscopy (FTIR-ATR) in close correlation with dynamic vapor sorption (DVS). The studies indicated that C-PET nanofibrous mats shows improved mechanical properties compared to collagen samples. A correlation between morphological, structural and cytotoxic proprieties of the studied samples were emphasized and the results suggest that the prepared nanofiber mats could be a promising candidate for tissue-engineering applications, especially dermal applications.

【 授权许可】

Unknown