Perspective on Clinically-Relevant Antimicrobial Resistant Enterobacterales in Food: Closing the Gaps Using Genomics

Frontiers in Sustainable Food Systems

Sandra Cortés¹  Andrea I. Moreno-Switt³  Jose M. Munita⁵  Francisca P. Álvarez⁶  Constanza Díaz-Gavidia⁶ 

[1] Centro de Desarrollo Urbano Sustentable, Pontificia Universidad Católica de Chile, Santiago, Chile;Departamento de Salud Pública, Escuela de Medicina, Advanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile, Santiago, Chile;Escuela de Medicina Veterinaria, Pontificia Universidad Católica de Chile, Santiago, Chile;Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile;Genomics and Resistant Microbes Group, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago, Chile;Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile;

关键词: antimicrobial resistance;    genomics;    clinically relevant bacteria;    Escherichia coli;    Klebsiella pneumoniae;    food safety;   

DOI  :  10.3389/fsufs.2021.667504

来源: DOAJ

【 摘 要 】

Antimicrobial resistance is one of the most important public health concerns—it causes 700,000 deaths annually according to the World Health Organization (WHO). Enterobacterales such as E. coli and Klebsiella pneumoniae, have become resistant to many relevant antimicrobials including carbapenems and extended spectrum cephalosporins. These clinically relevant resistant Enterobacterales (CRRE) members are now globally distributed in the environment including different food types (meats, produce, dairy). Unlike known foodborne pathogens, CRRE are not usually part of most food surveillance systems. However, numerous reports of CRRE highlight the importance of these bacteria in food and have been shown to contribute to the overall crisis of antimicrobial resistance. This is especially important in the context of carriage of these pathogens by immuno-compromised individuals. CRRE infections upon consumption of contaminated food could colonize the human gastrointestinal tract and eventually be a source of systemic infections such as urinary tract infections or septicemia. While different aspects need to be considered to elucidate this, whole genome sequencing along with metadata could be used to understand genomic relationships of CRRE obtained from foods and humans, including isolates from clinical infections. Once robust scientific data is available on the role of CRRE in food, countries could move forward to better survey and control CRRE in food.

【 授权许可】

Unknown