Principles underlying the complex dynamics of temperature entrainment by a circadian clock

iScience

Christoph Schmal¹  Abhishek Upadhyay²  Hanspeter Herzel²  Saskia Grabe²  Till Roenneberg³  Cornelia Madeti³  Philipp Burt³  Martha Merrow⁴ 

[1]Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland

[2]Institute for Theoretical Biology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany

[3]Institute for Theoretical Biology, Faculty of Life Sciences, Humboldt-Universität zu Berlin, Unter den Linden 6, 10117 Berlin, Germany

[4]Institute of Medical Psychology, Faculty of Medicine, LMU Munich, Goethestrasse 31, 80336 Munich, Germany

关键词: Chronobiology;    Systems biology;    In silico biology;    Plant biology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling.

【 授权许可】

Unknown