Synthesis, Characterization, Functionalization and Bio-Applications of Hydroxyapatite Nanomaterials: An Overview

International Journal of Nanomedicine

关键词: hydroxyapatite nanomaterial;    nanoparticle;    calcium phosphate;    drug delivery system;    composite materials;    biomimetic;   

DOI  :  

来源: DOAJ

【 摘 要 】

Muhammad Usman Munir,1 Sajal Salman,2 Ayehsa Ihsan,3 Tilal Elsaman1 1Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72388, Saudi Arabia; 2Faculty of Pharmacy, University of Central Punjab, Lahore, 54000, Pakistan; 3Nanobiotech Group, Industrial Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, PakistanCorrespondence: Muhammad Usman Munir, Email [e-mail]: Hydroxyapatite (HA) is similar to natural bone regarding composition, and its structure favors in biomedical applications. Continuous research and progress on HA nanomaterials (HA-NMs) have explored novel fabrication approaches coupled with functionalization and characterization methods. These nanomaterials have a significant role in many biomedical areas like sustained drug and gene delivery, bio-imaging, magnetic resonance, cell separation, and hyperthermia treatment due to their promising biocompatibility. This review highlighted the HA-NMs chemical composition, recent progress in synthesis methods, characterization and surface modification methods, ion-doping, and role in biomedical applications. HA-NMs have a substantial role as drug delivery vehicles, coating material, bone implant, coating, ceramic, and composite materials. Here, we try to summarize an overview of HA-NMs with the provision of future directions.Graphical Abstract: Keywords: hydroxyapatite nanomaterial, nanoparticle, calcium phosphate, drug delivery system, composite materials, biomimetic

【 授权许可】

Unknown