Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration

Polymers

Kuat Kassymbek¹  Arman Saparov¹  Zharylkasyn Zharkinbekov¹  Murat Baidarbekov²  EllinaA. Mun³  Gulshakhar Kudaibergen⁴  Vyacheslav Ogay⁴ 

[1] Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, Kazakhstan;Research Institute of Traumatology and Orthopedics, Nur-Sultan 010000, Kazakhstan;School of Sciences and Humanities, Nazarbayev University, Nur-Sultan 010000, Kazakhstan;Stem Cell Laboratory, National Center for Biotechnology, Nur-Sultan 010000, Kazakhstan;

关键词: polymer;    nanoparticle;    microparticle;    drug delivery system;    bone tissue regeneration;   

DOI  :  10.3390/polym12122881

来源: DOAJ

【 摘 要 】

Despite the high regenerative capacity of bone tissue, there are some cases where bone repair is insufficient for a complete functional and structural recovery after damage. Current surgical techniques utilize natural and synthetic bone grafts for bone healing, as well as collagen sponges loaded with drugs. However, there are certain disadvantages associated with these techniques in clinical usage. To improve the therapeutic efficacy of bone tissue regeneration, a number of drug delivery systems based on biodegradable natural and synthetic polymers were developed and examined in in vitro and in vivo studies. Recent studies have demonstrated that biodegradable polymers play a key role in the development of innovative drug delivery systems and tissue engineered constructs, which improve the treatment and regeneration of damaged bone tissue. In this review, we discuss the most recent advances in the field of polymer-based drug delivery systems for the promotion of bone tissue regeneration and the physical-chemical modifications of polymers for controlled and sustained release of one or more drugs. In addition, special attention is given to recent developments on polymer nano- and microparticle-based drug delivery systems for bone regeneration.

【 授权许可】

Unknown