The Reversal of Drug-Resistance in Tumors Using a Drug-Carrying Nanoparticular System

International Journal of Molecular Sciences

Kyung Taek Oh²  Hye Jung Baik³  A Hyeong Lee³  Young Taik Oh⁴  Yu Seok Youn¹ 

[1] College of Pharmacy, Pusan National University, Jangjun-dong, Geumjeong-gu, Busan 609-735, Korea; E-Mail:;College of Pharmacy, Chung-Ang University, 221 Heukseok dong, Seoul 155-756, Korea; E-Mail:;Division of Biotechnology, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Korea; E-Mails:;Department of Diagnostic Radiology, Yonsei University College of Medicine, Seodaemun-ku Shinchon-dong 134, Seoul, 120-752, Korea; E-Mail:

关键词: multi-drug resistance;    nanoparticle;    tumor treatment;    drug delivery system;   

DOI  :  10.3390/ijms10093776

来源: mdpi

【 摘 要 】

Medical applications of nanoparticular systems have attracted considerable attention because of their potential use in therapeutic targeting of disease tissues and their lower level of toxicity against healthy tissue, relative to traditional pharmaceutical drugs. The use of nanoparticular systems has been shown to overcome the limitations of most anticancer drugs in clinical applications. In particular, the improved performance of smarted nanoparticular system for solving the drug resistance problems that typically interrupt tumor treatment has provided a promising strategy for successful tumor chemotherapy. This review highlights recent studies that have examined the therapeutic effect of nanoparticular systems on drug-resistant tumors and presents insight on how they work.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.