Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Dominik Diesing¹  Siyao Li¹  Klaus Fliessbach²  Barbara Kofler³  Eike Jakob Spruth⁴  Oliver Peters⁵  Slawek Altenstein⁵  Josef Priller⁵  Michael Heneka⁶  Annika Spottke⁶  Frederic Brosseron⁶  Frank Jessen⁶  Janna Rudolph⁶  Steffen Wolfsgruber⁶  Michael Wagner⁶  Anja Schneider⁶  Jens Wiltfang⁷  Claudia Bartels⁷  Daniel Bittner⁸  Wenzel Glanz⁸  Laura Dobisch⁸  Katharina Buerger⁹  Ingo Kilimann^1,10  Stefan Teipel^1,10  Martina Buchmann^1,11  Christoph Laske^1,11  Daniel Janowitz^1,12  David Berron^1,13  Arturo Cardenas‐Blanco^1,13  Hartmut Schütze^1,13  Coraline Metzger^1,13  Emrah Düzel^1,13  Chris I. Baker^1,14  Wilma A. Bainbridge^1,14 

[1] Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt‐Universität zu Berlin, Berlin Institute of Health, Institute of Psychiatry and PsychotherapyBerlinGermany;Clinic for NeurologyUniversity Hospital MagdeburgMedical FacultyMagdeburgGermany;Department of Neurodegeneration and Geriatric PsychiatryUniversity Hospital BonnBonnGermany;Department of Psychiatry and PsychotherapyCharitéBerlinGermany;German Center for Neurodegenerative Diseases (DZNE)BerlinGermany;German Center for Neurodegenerative Diseases (DZNE)BonnGermany;German Center for Neurodegenerative Diseases (DZNE)GoettingenGermany;German Center for Neurodegenerative Diseases (DZNE)MagdeburgGermany;German Center for Neurodegenerative Diseases (DZNE)MunichGermany;German Center for Neurodegenerative Diseases (DZNE)RostockGermany;German Center for Neurodegenerative Diseases (DZNE)TübingenGermany;Institute for Stroke and Dementia Research, University HospitalLMU MunichMunichGermany;Institute of Cognitive Neurology and Dementia Research, Otto‐von‐Guericke University MagdeburgMagdeburgGermany;Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of HealthBethesdaMDUSA;

关键词: Alzheimer's disease (AD);    Subjective cognitive decline (SCD);    Mild cognitive impairment (MCI);    Memorability;    Diagnostic assessment;    Image analysis;   

DOI  :  10.1016/j.dadm.2019.07.005

来源: DOAJ

【 摘 要 】

Abstract Introduction Impaired long‐term memory is a defining feature of mild cognitive impairment (MCI). We tested whether this impairment is item specific, limited to some memoranda, whereas some remain consistently memorable. Methods We conducted item‐based analyses of long‐term visual recognition memory. Three hundred ninety‐four participants (healthy controls, subjective cognitive decline [SCD], and MCI) in the multicentric DZNE‐Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs. Results We observed consistent memorability for images in healthy controls, SCD, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set. Discussion Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.

【 授权许可】

Unknown