Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease

NEUROBIOLOGY OF AGING

卷:36

Article

Babiloni, Claudio^1,2  Del Percio, Claudio²  Boccardi, Marina³  Lizio, Roberta²  Lopez, Susanna¹  Carducci, Filippo¹  Marzano, Nicola⁴  Soricelli, Andrea^4,5  Ferri, Raffaele⁶  Triggiani, Antonio Ivano⁷  Prestia, Annapaola³  Salinari, Serenella⁸  Rasser, Paul E.^9,10  Basar, Erol¹¹  Fama, Francesco¹²  Nobili, Flavio¹²  Yener, Gorsev^11,13,14,15  Emek-Savas, Derya Durusu^11,13  Gesualdo, Loreto¹⁶  Mundi, Ciro¹⁷  Thompson, Paul M.¹⁸  Rossini, Paolo M.^2,19  Frisoni, Giovanni B.³ 

[1] Univ Roma La Sapienza, Dept Physiol & Pharmacol, I-00185 Rome, Italy

[2] IRCCS San Raffaele Pisana, Dept Neurosci, Rome, Italy

[3] IRCCS Ctr S Giovanni di Dio FBF, LENITEM Lab Epidemiol Neuroimaging & Telemed, Brescia, Italy

[4] IRCCS SDN, Dept Integrated Imaging, Naples, Italy

[5] Univ Naples Parthenope, Dept Studies Inst & Territorial Syst, Naples, Italy

[6] IRCCS Oasi Inst Res Mental Retardat & Brain Aging, Dept Neurol, Troina, Enna, Italy

[7] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy

[8] Univ Roma La Sapienza, Dept Informat & Syst Antonio Ruberti, I-00185 Rome, Italy

[9] Univ Newcastle, Ctr Translat Neurosci & Mental Hlth Res, Newcastle, NSW 2300, Australia

[10] Schizophrenia Res Inst, Darlinghurst, NSW, Australia

[11] Istanbul Kultur Univ, Brain Dynam Cognit & Complex Syst Res Ctr, Istanbul, Turkey

[12] Univ Genoa, Dept Neurosci DINOGMI, Neurol Clin, I-16126 Genoa, Italy

[13] Dokuz Eylul Univ, Dept Neurosci, Izmir, Turkey

[14] Dokuz Eylul Univ, Brain Dynam Multidisciplinary Res Ctr, Izmir, Turkey

[15] Dokuz Eylul Univ, Sch Med, Dept Neurol, Izmir, Turkey

[16] Univ Bari, DETO, Bari, Italy

[17] Osped Riuniti Foggia, Dept Neurol, Foggia, Italy

[18] Univ Calif Los Angeles, Sch Med, Dept Neurol & Psychiat, Imaging Genet Ctr,Lab Neuro Imaging, Los Angeles, CA USA

[19] Univ Cattolica Sacro Cuore, Inst Neurol, Dept Geriatr Neurosci & Orthoped, I-00168 Rome, Italy

关键词: Mild cognitive impairment (MCI);    Alzheimer's disease (AD);    Electroencephalography (EEG);    Magnetic resonance imaging (MRI);    Gray matter density (GMD);   

DOI  :  10.1016/j.neurobiolaging.2014.09.011

来源: Elsevier

【 摘 要 】

Occipital sources of resting-state electroencephalographic (EEG) alpha rhythms are abnormal, at the group level, in patients with amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Here, we evaluated the hypothesis that amplitude of these occipital sources is related to neuro-degeneration in occipital lobe as measured by magnetic resonance imaging. Resting-state eyes-closed EEG rhythms were recorded in 45 healthy elderly (Nold), 100 MCI, and 90 AD subjects. Neuro-degeneration of occipital lobe was indexed by weighted averages of gray matter density, estimated from structural MRIs. EEG rhythms of interest were alpha 1 (8-10.5 Hz) and alpha 2 (10.5-13 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results showed a positive correlation between occipital gray matter density and amplitude of occipital alpha 1 sources in Nold, MCI, and AD subjects as a whole group (r = 0.3, p = 0.000004, N = 235). Furthermore, there was a positive correlation between the amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Examination score across all subjects (r = 0.38, p = 0.000001, N = 235). Finally, amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects (sensitivity: 87.8%; specificity: 66.7%; area under the receiver operating characteristic curve: 0.81). These results suggest that the amplitude of occipital sources of resting- state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging. (C) 2015 Elsevier Inc. All rights reserved.

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