CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Dominik Diesing¹  Siyao Li¹  Oliver Speck²  Barbara Kofler³  Eike Jakob Spruth⁴  Alfredo Ramirez⁵  Oliver Peters⁶  Slawek Altenstein⁶  Josef Priller⁶  Martin Reuter⁷  Michael Heneka⁷  Annika Spottke⁷  Frederic Brosseron⁷  Frank Jessen⁷  Klaus Fliessbach⁷  Janna Rudolph⁷  Steffen Wolfsgruber⁷  Michael Wagner⁷  Anja Schneider⁷  Jens Wiltfang⁸  Claudia Bartels⁸  Daniel Bittner⁹  Wenzel Glanz⁹  Peter Nestor⁹  Matthew Betts⁹  Laura Dobisch⁹  Katharina Buerger^1,10  Ingo Kilimann^1,11  Martin Dyrba^1,11  Stefan Teipel^1,11  Martina Buchmann^1,12  Christoph Laske^1,12  Daniel Janowitz^1,13  David Berron^1,14  Arturo Cardenas‐Blanco^1,14  Hartmut Schütze^1,14  Gabriel Ziegler^1,14  Coraline Metzger^1,14  Yi Chen^1,14  Emrah Düzel^1,14 

[1] Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt‐Universität zu Berlin, and Berlin Institute of Health, Institute of Psychiatry and PsychotherapyBerlinGermany;Department of Biomagnetical ResonanceMagdeburgGermany;Department of Neurodegeneration and Geriatric PsychiatryUniversity Hospital BonnBonnGermany;Department of Psychiatry and PsychotherapyBerlinGermany;Department of PsychiatryUniversity of CologneMedical FacultyCologneGermany;German Center for Neurodegenerative Diseases (DZNE)BerlinGermany;German Center for Neurodegenerative Diseases (DZNE)BonnGermany;German Center for Neurodegenerative Diseases (DZNE)GoettingenGermany;German Center for Neurodegenerative Diseases (DZNE)MagdeburgGermany;German Center for Neurodegenerative Diseases (DZNE)MunichGermany;German Center for Neurodegenerative Diseases (DZNE)RostockGermany;German Center for Neurodegenerative Diseases (DZNE)TübingenGermany;Institute for Stroke and Dementia Research, University HospitalMunichGermany;Institute of Cognitive Neurology and Dementia Research, Otto‐von‐Guericke University MagdeburgMagdeburgGermany;

关键词: Alzheimer's disease (AD);    Subjective cognitive decline (SCD);    Mild cognitive impairment (MCI);    Longitudinal;    Cerebrospinal fluid (CSF);    Aβ42;   

DOI  :  10.1016/j.dadm.2018.10.003

来源: DOAJ

【 摘 要 】

Abstract Introduction We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. Methods We conducted a cross‐sectional analysis of the observational, multicentric DZNE‐Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy‐six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). We assessed the correlation between CSF biomarkers and whole‐brain functional magnetic resonance imaging novelty responses to scene images. Results Total tau levels were specifically and negatively associated with novelty responses in the right amygdala and right hippocampus. Mediation analyses showed no evidence that these associations were dependent on the volume of hippocampus/amygdala. No relationship was found between phosphorylated‐tau or Aβ42 levels and novelty responses. Discussion Our data show that CSF levels of total tau are associated with anatomically specific reductions in novelty processing, which cannot be fully explained by atrophy.

【 授权许可】

Unknown