Effects of ABCB1 gene polymorphisms on autonomic nervous system activity during atypical antipsychotic treatment in schizophrenia

BMC Psychiatry

Masataka Taguri¹  Masatoshi Miyauchi²  Saki Hattori²  Akira Suda²  Ikuko Kishida²  Yohko Shiraishi²  Yoshio Hirayasu²  Mami Fujibayashi³  Toshio Moritani⁴  Norio Ishii⁵  Chie Ishii⁵  Natsuki Tsujita⁶ 

[1] Department of Biostatistics, Yokohama City University School of Medicine;Department of Psychiatry, Yokohama City University School of Medicine;Division of Physical and Health Education, Setsunan University;Faculty of General Education, Kyoto Sangyo University;Fujisawa Hospital;Graduate School of Human and Environmental Studies, Kyoto University;

关键词: Schizophrenia;    Atypical antipsychotic drug;    Heart rate variability;    P-glycoprotein;    Autonomic nervous system;    ABCB1 gene;   

DOI  :  10.1186/s12888-018-1817-5

来源: DOAJ

【 摘 要 】

Abstract Background There are interindividual differences in the adverse effects of atypical antipsychotics, which include autonomic nervous system (ANS) dysfunction. Accordingly, to clarify the interindividual differences in the adverse effects of specific atypical antipsychotics in schizophrenia, we investigated the association between ANS dysfunction and ATP-binding cassette transport sub-family B member 1 (ABCB1) gene polymorphisms in patients with schizophrenia. Methods In total, 233 Japanese patients with schizophrenia participated in this study. All of the participants received an atypical antipsychotic as monotherapy: 89 participants received risperidone, 69 olanzapine, 48 aripiprazole, and 27 quetiapine. ANS activity was assessed by means of a power spectral analysis of heart rate variability. Four single nucleotide polymorphisms (SNPs) in ABCB1 (rs1045642, rs1128503, rs2032582, and rs2235048) were genotyped using the TaqMan method. Results For aripiprazole, sympathetic and total autonomic nervous activities were significantly lower in the rs1045642 T allele carrier–rs2235048 C allele carrier group than in the rs1045642 non-T allele carrier–rs2235048 non-C allele carrier group. In addition, in the aripiprazole group, the T-C-T-A haplotype (rs1045642-rs2235048-rs1128503-rs2032582) was associated with decreased ANS activity. However, there were no significant associations between ANS activity and ABCB1 gene polymorphisms in the risperidone, olanzapine, and quetiapine groups. Multiple regression analysis revealed that sympathetic and total nervous activities were significantly associated with the ABCB1 rs1045642–rs2235048 genotype and the T-C-T-A haplotype (rs1045642-rs2235048-rs1128503-rs2032582). Conclusion We suggest that ABCB1 genetic polymorphisms affect aripiprazole-related ANS dysfunction but do not affect risperidone-, olanzapine-, or quetiapine-related ANS dysfunction.

【 授权许可】

Unknown