Dose-dependent effect of antipsychotic drugs on autonomic nervous system activity in schizophrenia

BMC Psychiatry

Research Article

Masataka Taguri¹  Taku Furuno²  Chiaki Kawanishi²  Yoshio Hirayasu²  Yohko Iwamoto³  Ikuko Kishida³  Chie Ishii⁴  Norio Ishii⁴  Toshio Moritani⁵  Mami Fujibayashi⁶ 

[1] Department of Biostatistics and Epidemiology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan;Department of Psychiatry, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan;Department of Psychiatry, Yokohama City University School of Medicine, 3-9, Fukuura, Kanazawa-ku, 236-0004, Yokohama, Japan;Fujisawa Hospital, Kanagawa Prefecture, Japan;Fujisawa Hospital, Kanagawa Prefecture, Japan;Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan;Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan;The Division of Physical and Health Education, Setsunan University, Osaka, Japan;

关键词: Adverse drug effect;    Antipsychotic drug;    Autonomic nervous system;    Heart rate variability;    Schizophrenia;   

DOI  :  10.1186/1471-244X-12-199

 received in 2012-05-11, accepted in 2012-11-02,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundAntipsychotic drugs are considered a trigger factor for autonomic dysregulation, which has been shown to predict potentially fatal arrhythmias in schizophrenia. However, the dose-dependent effect of antipsychotic drugs and other psychotropic drugs on autonomic nervous system (ANS) activity remain unclear. The purpose of this study was to investigate the dose-dependent effect of antipsychotic drugs and other clinical factors on ANS activity in an adequate sample size of patients with schizophrenia.MethodsA total of 211 Japanese patients with schizophrenia and 44 healthy subjects participated in this study. ANS activity was assessed by means of heart rate variability (HRV) power spectral analysis. Antipsychotic drug treatment and various clinical factors were investigated for each participant. The patient group was categorized into three subgroups according to daily dose of antipsychotic drug, and HRV was compared between groups.ResultsThe results showed significantly decreased low-frequency and high-frequency components of HRV in the patient group compared to the control group. The high-dose group showed a significantly lower HRV than the medium-dose group and an even lower HRV than the low-dose group. In addition, a significant association between HRV and antipsychotic drug dose was identified by multiple regression analysis. HRV was not associated with age, sex, body mass index, duration of illness, or daily dose of other psychotropic drugs.ConclusionThese results suggest that antipsychotic drugs exert a significant dose-dependent effect on the extent of decline in ANS activity, and that optimal antipsychotic medication is required to avoid possible cardiovascular adverse events in patients with schizophrenia.

【 授权许可】

Unknown   
© Iwamoto et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.