Accelerated Skin Wound Healing Using Flexible Photovoltaic-Bioelectrode Electrical Stimulation

Micromachines

Waqar Ali Memon¹  Kamran Amin¹  Zexing Deng²  Xiangdong Qi³  Chao Han³  Junfei Huang⁴  Yang Yang⁵  Aodi Zhangji⁶  Xinlan Liu⁷  Kun Zhou⁸  Yuheng Wang⁹  Kaige Yu⁹  Wanlei Gao⁹  Xufeng Tong⁹  Kai Chen⁹  Yuxin Chen^1,10 

[1] CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China;College of Materials Science and Engineering, Xi’an University of Science and Technology, Xi’an 710054, China;Department of Plastic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510515, China;Department of Plastic and Aesthetic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China;Department of Plastic and Reconstructive Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, China;Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China;Medical College, Ningbo University, Ningbo 315000, China;School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China;The Faculty of Electrical Engineering and Computer Science, Ningbo University, Ningbo 315211, China;The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China;

关键词: flexible photovoltaic-bioelectrode;    MEMS;    electrical stimulation;    wound healing;   

DOI  :  10.3390/mi13040561

来源: DOAJ

【 摘 要 】

Owing to the complex and long-term treatment of foot wounds due to diabetes and the limited mobility of patients, advanced clinical surgery often uses wearable flexible devices for auxiliary treatment. Therefore, there is an urgent need for self-powered biomedical devices to reduce the extra weight. We have prepared an electrically stimulated MEMS (Micro Electromechanical System) electrode integrated with wearable OPV (Organic photovoltaic). The wearable OPV is constructed of a bio-affinity PET-ITO substrate and a hundred-nanometer organic layer. Under sunlight and near-infrared light irradiation, a voltage and current are supplied to the MEMS electrode to generate an exogenous lateral electric field directed to the center of the wound. The results of in vitro cell experiments and diabetic skin-relieving biological experiments showed the proliferation of skin fibroblasts and the expression of transforming growth factors increased, and the skin wounds of diabetic mouse healed faster. Our research provides new insights for the clinical treatment of diabetes.

【 授权许可】

Unknown