Integrative Bioengineering Institute

Eddington, David ; Magin,L,Richard ; Hetling, John ; Cho, Michael

关键词: BIOLOGY;    CELL CULTURES;    DESIGN;    DIFFUSION;    MEDICINE;    PLATES Nanotechnology;    MEMS;    bioengineering;    microfabrfication;    microfluidics;   

DOI  :  10.2172/945219
RP-ID  :  DOE/ER
PID  :  OSTI ID: 945219
Others  :  TRN: US201006%%476

学科分类：工程和技术（综合）

美国|英语

来源: SciTech Connect

【 摘 要 】

Microfabrication enables many exciting experimental possibilities for medicine and biology that are not attainable through traditional methods. However, in order for microfabricated devices to have an impact they must not only provide a robust solution to a current unmet need, but also be simple enough to seamlessly integrate into standard protocols. Broad dissemination of bioMEMS has been stymied by the common aim of replacing established and well accepted protocols with equally or more complex devices, methods, or materials. The marriage of a complex, difficult to fabricate bioMEMS device with a highly variable biological system is rarely successful. Instead, the design philosophy of my lab aims to leverage a beneficial microscale phenomena (e.g. fast diffusion at the microscale) within a bioMEMS device and adapt to established methods (e.g. multiwell plate cell culture) and demonstrate a new paradigm for the field (adapt instead of replace). In order for the field of bioMEMS to mature beyond novel proof-of-concept demonstrations, researchers must focus on developing systems leveraging these phenomena and integrating into standard labs, which have largely been ignored. Towards this aim, the Integrative Bioengineering Institute has been established.